Wednesday 26 August 2015

Nanocapsules are drug delivery agents within the size range of 10nm to 1000 nm that are normally composed of a capsule shell and a hollow space in which desired substance or drug molecules are embedded. The ultrafine size of nanocapsules match the biological composition of human body such as RBCs which permits enhanced permeation and retention (EPR) through narrow channels during diffusion. Due to this EPR effect, nanocapsules are used as drug carriers. Nanocapsules can be formulation using various methods such as loading of drug molecules into hollow polyelectrolyte shell and another method being electrostatic layer by layer (LbL) technique. These latest LbL self-assembled polyelectrolyte capsules provide an efficient way to perform multiple drug delivery tasks simultaneously. Some nanocapsules are used for targeted drug delivery in anti-tumor and anti-tuberculosis therapies wherein the outer sphere of nanocapsules is fabricated by the lithography technique. Lipid nanocapsules (DNA LNCs) and multimodular systems (DNA MMS) are used in gene therapy.

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Global investment in nanotechnology research has witnessed a six fold increase during the last decade. Consequently, nanotechnology will completely revolutionize the industrial processes in the near future due to its remarkable economic potential. Some of the key drivers for the market growth include investments and breakthroughs in biomedical, pharmaceutical, electronics, molecular and diagnostic fields. Besides, these nanocapsules are being increasingly used in agrochemicals, environment and wastewater treatments, genetic engineering, consumer goods and cosmetic procedures. Some of the most advanced future applications would be nanocapsule dressings to deliver antibiotics aiding faster wound healing without invasion to the skin. These nanocapsule bandages would be consistently demanded by defence and protection forces as they need not be changed periodically. According to the experts, electronics and magnetic sector will be the largest potential market for nanocapsules, followed by biopharmaceutical industry, catalysis, energy and engineering. However, growth in the nanocapsules market will also pose new challenges with respect to the toxicity and environmental impact of nanocapsules. Recently efforts have been made to overcome these drawbacks by developing eco-friendly versatile nanocapsules. For instance, nanocapsules introduced by the Center for Self-assembly and Complexity, Institute for Basic Science (IBS). Other factors such as cost escalation and consequences on the global economy especially in cases of under-developed economies with poor R&D investment would exhibit low social and ethical acceptance of nanocapsules.

Funding for nanotechnology is soaring worldwide at a competitive level, with each major economic power and many developed economies making a substantial investment to revamp their industrial and postindustrial supply chains. Technological inventions and discoveries in nanotechnology would cause tremendous growth in the global nanocapsule market. Due to a variety of potential applications, nanotechnology is expected to become the key technology in the near future. U.S. has invested around USD 3.7 billion through its National Nanotechnology Initiative for research activities. The European Union had spent approximately USD 1.2 billion and Japan USD 750 million by 2012. Moreover, there is a steady demand for medically advanced procedures in developed as well as developing regions having a well-established healthcare infrastructure. In the Asia Pacific region, the demand for nanocapsules is projected to rise owing to the high disease burden of tuberculosis and cancer. Some of the key factors that are likely to contribute toward the market growth are growing awareness about genetic counselling, genetic disorders, high prevalence of tuberculosis and multi-drug resistant tuberculosis, increasing trend in cancer and tumor ailments and surging demand for oncological treatments.

Presently, nanocapsules are under different stages of clinical trial phases facing several hurdles to gain market entry. However, few commercially available nanocapsules which are now commercially used as several pigments in sunscreen, scratch resistance coatings, catalysts, and biomarkers. Some of the key market players for these commercially available nanocapsules are Abraxis, Artificial Cell Technologies, Inc., BioDelivery Sciences International, Inc., Biophan Technologies, Inc., Cornerstone Pharmaceuticals, Inc., Genetic Immunity, Inc., Keystone Nano, Inc., Makefield Therapeutics, Inc., Nanospectra Biosciences, Inc., and Mersana Therapeutics, Inc.

This research report analyzes this market on the basis of its market segments, major geographies, and current market trends. This report provides comprehensive analysis of
Market growth drivers
Factors limiting market growth
Current market trends
Market structure
Market projections for upcoming years

This report is a complete study of current trends in the market, industry growth drivers, and restraints. It provides market projections for the coming years. It includes analysis of recent developments in technology, Porter’s five force model analysis and detailed profiles of top industry players. The report also includes a review of micro and macro factors essential for the existing market players and new entrants along with detailed value chain analysis.

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Monday 24 August 2015


Ischemia is characterized by a specific condition, where there is an insufficient flow of blood supply to tissues, leading to a shortage of oxygen and glucose which is needed for cellular metabolism. Due to an obstruction and insufficient blood supply, various organs and tissue get severely damaged. Ischemia, if left untreated, may lead to tissue death. Ischemia is primarily caused by thrombosis of an artery, embolism, vasculitis, atherosclerosis, coronary artery disease and peripheral artery disease. There are various types of ischemia with different diagnosis and treatment methods involved with each type of ischemia. 


Based on the types, ischemia market can be segmented as follows:
  • Myocardial ischemia: Due to blockage of a coronary artery, there is a limited blood flow to the heart muscle and is referred to as myocardial ischemia. Symptoms include arm pain, chest pain, breathlessness, dizziness, weakness, heart palpitations and clammy skin.
  • Cerebral ischemia: Cerebral ischemia occurs when there is a temporary deficiency of blood supply to an individual’s brain. Symptoms include difficulty in speaking, lack of coordination, body movement problems, vision impairment and unconsciousness.
  • Intestinal ischemia: Ischemia affects intestine too, and this condition is known as intestinal ischemia. Various symptoms include abdominal pain, fever, diarrhea, vomiting, bloody stools and weight loss.
  • Hepatic ischemia: In hepatic ischemia, an individual’s liver does not receive enough blood supply. Hypotension is the prime cause of hepatic ischemia and symptoms include dehydration, heart failure, severe bleeding and abnormal heart rhythms. 
  • Acute limb ischemia: Decreased level of blood flow to hands, feet and legs leads to acute limb ischemia. Symptoms include skin ulcers, skin sores and severe pain.
Based on treatment, the ischemia can be segmented as follows:
  • Medications:
    • Angiotensin-converting enzyme (ACE) inhibitors
    • Anticoagulants
    • Aspirin
    • Analgesics
    • Beta blockers
    • Nitroglycerine
  • Surgery methods:
    • Angioplasty, also referred to as percutaneous coronary intervention (PCI)
    • Coronary artery bypass surgery
    • Embolectomy
    • Aortomesenteric bypass and resection of bowel
Based on geography, the ischemia market can be segmented into four major regions: North America, Europe, Asia Pacific and Rest of the World (RoW). Out of these regions, North America dominates the ischemia market followed by Europe. The prime factors which would drive the growth of the market in these regions are growing prevalence of high cholesterol diseases, increasing incidences of obesity and physical inactivity. Moreover, technological advancements and increasing competition from small market players have further fueled the growth of ischemia market. According to a survey, approximately 1.5 million cases of myocardial ischemia occur annually in the United States. Moreover, technological advancements and increasing competition from small market players have further fueled the growth of ischemia market. Asia Pacific is one of the most promising markets for the growth of ischemia market due to easy market penetration. 

The factors which would augment the growth of the market in Asia Pacific are increasing geriatric population, high prevalence of unhealthy lifestyle amongst the population and increasing awareness regarding the malignant effects of ischemia. Other factors such as tax benefits and increasing disposable incomes of the population would further propel the growth of ischemia market.


Various biopharmaceutical companies are constantly coming up with novel therapeutics for the treatment of ischemia. Some of the top players operating in the ischemia market are Sanofi, Pfizer, Inc., Medicure, Inc., Baxter International, Boston Scientific Corporation, Vasade Biosciences, Inc. and others.

This research report analyzes this market on the basis of its market segments, major geographies, and current market trends. Geographies analyzed under this research report include
North America
Asia Pacific
Europe
Rest of the World

This report provides comprehensive analysis of
Market growth drivers
Factors limiting market growth
Current market trends
Market structure
Market projections for upcoming years

This report is a complete study of current trends in the market, industry growth drivers, and restraints. It provides market projections for the coming years. It includes analysis of recent developments in technology, Porter’s five force model analysis and detailed profiles of top industry players. The report also includes a review of micro and macro factors essential for the existing market players and new entrants along with detailed value chain analysis.

Reasons for Buying this Report
This report provides pin-point analysis for changing competitive dynamics
It provides a forward looking perspective on different factors driving or restraining market growth
It provides a six-year forecast assessed on the basis of how the market is predicted to grow
It helps in understanding the key product segments and their future
It provides pin point analysis of changing competition dynamics and keeps you ahead of competitors
It helps in making informed business decisions by having complete insights of market and by making in-depth analysis of market segments
    

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